Yeah, I do it more now than I used to, but it's difficult, because of the tendency to run into a wacky creation never seen before. The most important thing, in my experience, is to make sure that not all of your decks have the same weaknesses. If all of your decks lack the disruption/speed necessary to beat combo, then you will die miserably when you face combo. If your decks can all be shut down with a Null Rod, then you deserve to run into Null Rod every game...
It's funny to watch how bad players metagame. Usually they do absolutely nothing (which is why they are bad players) and lose to the same tricks over and over. But it's even funnier to watch them fill their decks with lifegain against Donate, splash blue for countermagic to beat permission, build bigger decks to survive against milling, run color hosers that don't work with their strategies...