Let's see...
First, EOT, use the Goblet on ya
Untap, upkeep, Draw
Attack with the Skirge for 3
If successful and no responses, use the Goblet on ya for the win.
If you do have a response during combat, will hold up and not use the Goblet yet...
Spidey: 5
Hand: 1
Library: 25
Poison Ctrs: 2
Battlefield:
(U,U,U) Plains x3
(U,U,U) Swamp x4
Onyx Goblet (T: Target player loses a life)
(U) Akrasan Squire (1/1; Exalted)
(T) Slinking Skirge (2/1; Flying; 2, Sac ~: Draw a card)
Graveyard: Coercion, Disembowl, Roterothopter, Executioner's Capsule, Lose Hope, Nomads en-Kor, Dash Hope
Exile:
Mooseman: 4
Hand: 1
Library: 25
Battlefield:
(UT) Swamp
(U) Mountain
(UU) Forest
(U) Wall of Diffusion (0/5, Wall of Diffusion can block creatures with shadow.)
(T) Darkheart Sliver (3/3, All Slivers have "Sacrifice this creature: You gain 3 life.")
(U) Muscle Sliver (2/2, All Slivers get +1/+1)
Graveyard: Canopy Spider, Elvish Rite, Barbed Sliver, Metallic Sliver, Chime of Night, Spined Sliver, Virulent Sliver, Vampiric Link
Exile: